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J. William Straus

Associate Professor of Biology
  • Ph.D. 1981 Cellular and Developmental Biology, Washington University
  • A.B. 1975. Biology. Earlham College

Research Interests

Phagocytosis is a process by which cells engulf bacteria, protists, and other particulate materials. This process plays a critical role in both innate and adaptive immune responses as well as cellular nutrition. Internalized materials are normally oxidized and digested. My laboratory has been focused on the role of proteolytic enzymes in phagocytosis. Recent efforts utilized widefield fluorescent and confocal microscopy to visualize protease activity in living phagosomes of the protist Tetrahymena thermophila. Current work includes synthesis of novel fluorescent reagents for detecting and quantifying proteases in live cells, and developing reagents to trace how and when different proteases are delivered to maturing phagosomes.

I welcome the involvement of students in all of my research activities.

Teaching Interests

My recent teaching includes introductory BIOL 105 Parasitism, Immunity, and Human Biology, ENST 151 The Environmental Imagination, BIOL 232 Developmental Biology, BIOL 272 Biochemistry and NEUR 301 Neuroscience and Behavior Senior Seminar. I have advised independent research and senior theses for Environmental Studies, Chemistry, Biochemistry, and Biology majors.

Selected Publications

  • Koob, T.J. and J.W. Straus. 1998. On the role of egg jelly in Raja erinacea egg capsule. Bull. Mt. Des. Is. Biol. Lab 37, 117-119.
  • Straus, J.W. and T.J. Koob. 1997. Protease activity in albumin during development of the little skate Raja erinacea. Bull. Mt. Des. Is. Biol. Lab. 36, 111-113.
  • Straus, J.W. and M.L.. *Monge. 1997. Catechol oxidase from the skate nidamental gland: partial purification and characterization. Bull. Mt. Des. Is. Biol. Lab. 36, 108-110.
  • Straus, J.W., C.L. *Monian and D.L. Cox. 1993. Nidamental gland catechol oxidase in the little skate (Raja erinacea): latency caused by an endogenous low molecular weight factor. Comp. Biochem. Physio. 105B, 117-122.
  • Straus, J.W., N.C. *Rabidou, J.K. *Bogdany and D.L. Cox. 1993. Oxidative enzymes and the formation of egg capsules in the little skate (Raja erinacea) Bull.Mt. Des. Is. Biol. Lab 32, 14-16.

* student author